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Scientific Work


REVIEWS (In chronological order of peer-reviewed publication)

  1. Shenoy AT, and Orihuela CJ. Anatomical site-specific contributions of pneumococcal virulence determinants. Pneumonia 2016, 8:7 DOI: 10.1186/s41479-016-0007-9

  2. Shenoy AT, and Pradhan V. DNA methylation and silencing of gene expression: role in pathogenesis of systemic lupus erythematosus. Indian Jrnl Biotechnol. October 2017. Vol 16, pp 512-528

PRIMARY RESEARCH ARTICLES (In chronological order of peer-reviewed publication)

  1. Gilley RP, González-Juarbe N, Shenoy AT, Reyes LF, Dube PH, Restrepo MI, Orihuela CJ. Infiltrated macrophages die of pneumolysin-mediated necroptosis following pneumococcal myocardial invasion.  Infect Immun. 2016 Apr 22;84(5):1457-69. doi: 10.1128/IAI.00007-16. 

  2. Blanchette KA*, Shenoy AT*, Gilley RP, Milner II JD, McClure E, Hinojosa CA, Ferreira DM, King SJ, Gordon SB, Tettelin H, and Orihuela CJ. Neuraminidase A- exposed galactose promotes Streptococcus pneumoniae biofilm formation during colonization. Infect. Immun. October 2016 vol. 84 no. 10 2922-2932.

  3. Reyes LF, Restrepo MI, Hinojosa CA, Soni NJ, Shenoy AT, Gilley RP, Gonzalez-Juarbe N, Noda JR, Winter VT, de la Garza MA, Shade RE, Coalson JJ, Giavedoni LD, Anzueto A, and Orihuela CJ. A non-human primate model of severe pneumococcal pneumonia. PLoS ONE. November 2016 11(11): e0166092.doi:10.1371/journal.pone.0166092

  4. Ray C, Shenoy AT, Orihuela CJ, Gonzalez-Juarbe N. Killing of Serratia marcescens biofilms with chloramphenicol. Ann Clin Microbiol Antimicrob. 2017 Mar 29;16(1):19. doi: 10.1186/s12941-017-0192-2.

  5. González-Juarbe N, Bradley KM, Shenoy AT, Gilley RP, Reyes LF, Hinojosa CA, Restrepo MI, Dube PH, Bergman MA, Orihuela CJ.  Pore-forming toxin induced necroptosis is independent of death receptor signaling during bacterial pneumonia. Cell Death Differ. 2017 May;24(5):917-928. doi: 10.1038/cdd.2017.49.

  6. Lizcano A*, Akula Suresh Babu R*, Shenoy AT, Saville AM, Kumar N, D'Mello A, Hinojosa CA, Gilley RP, Segovia J, Mitchell TJ, Tettelin H, and Orihuela CJ. Transcriptional organization of psrP-secY2A2 and the impact of glycosyltransferase deletion on PsrP function. Microbes Infect. 2017 Apr 10. pii: S1286-4579(17)30043-6.

  7. Spencer BL, Saad JS, Shenoy AT, Orihuela CJ, Nahm MH. Position of O-acetylation within the capsular repeat unit impacts the biological properties of pneumococcal serotypes 33A and 33F. Infect Immun. 2017 Apr 24. pii: IAI.00132-17. doi: 10.1128/IAI.00132-17.

  8. Spencer BL, Shenoy AT, Orihuela CJ, Nahm MH. The pneumococcal serotype 15C capsule is partially O-acetylated and allows limited evasion of PPV23-elicited anti-serotype 15B antibodies. Clin Vaccine Immunol. 2017 Jun 21. pii: CVI.00099-17. doi: 10.1128/CVI.00099-17.

  9. Shenoy AT, Brissac T, Gilley RP, Kumar N, Gonzalez-Juarbe N, Wang Y, Hinkle WS, Daugherty SC, Shetty AC, Ott S, Tallon LJ, Deshane J, Tettelin H, and Orihuela CJ. Streptococcus pneumoniae in the heart subvert the host response through biofilm-mediated resident macrophage killing. PLOS Pathogens. 2017 Aug 25 ;13(8): doi: 10.1371/ journal. ppat.1006582

  10. Brissac T, Shenoy AT, Patterson LA, Orihuela CJ. Cell invasion and pyruvate oxidase derived H2O2 are critical for Streptococcus pneumoniae mediated cardiomyocyte killing. Infect Immun. 2017 Oct 23. pii: IAI.00569-17. doi: 10.1128/IAI.00569-17.

  11. Shenoy AT*, Beno SM*, Brissac T, Bell JW, Novak L, and Orihuela CJ. Severity and properties of cardiac damage caused by Streptococcus pneumoniae are strain dependent. PLOS One. 2018 Sep 14. 13(9): e0204032

  12. Shenoy AT*, Wasserman GA*, Arafa EI, Wooten AK, Smith NMS, Martin IMC, Jones MR, Quinton LJ, and Mizgerd JP. Lung CD4+ resident memory T cells remodel epithelial responses to accelerate neutrophil recruitment during pneumonia. Mucosal Immunol 2020 Mar;13(2):334-343. doi: 10.1038/s41385-019-0229-2.

  13. Guillon A, Arafa EI, Barker KA, Belkina AC, Martin I, Shenoy AT, Wooten AK, Lyon De Ana C, Dai A, Labadorf A, Hernandez Escalante J, Dooms H, Blasco H, Traber KE, Jones MR, Quinton LJ, and Mizgerd JP. Pneumonia recovery reprograms the alveolar macrophage pool. JCI Insight. 2020.

  14. Wooten AK, Shenoy AT, Arafa EI, Akiyama H, Martin IMC, Jones MR, Quinton LJ, Gummuluru S, Bai G, Mizgerd JP. Unique Roles for Streptococcus pneumoniae Phosphodiesterase 2 in Cyclic di-AMP Catabolism and Macrophage Responses. Front Immunol. 2020 Mar 31;11:554. doi: 10.3389/fimmu.2020.00554.

  15. Beno SM, Riegler AN, Gilley RP, Brissac T, Wang Y, Kruckow KL, Jadapalli JK, Wright GM, Shenoy AT, Stoner SN, Restrepo MI, Deshane JS, Halade GV, Gonzalez-Juarbe N and Orihuela CJ. Necroptosis inhibition prevents long-term cardiac damage during pneumococcal pneumonia and invasive disease. J Infect Dis. 2020 Jun 3:jiaa295. doi: 10.1093/infdis/jiaa295. 

  16. Shenoy AT, and Mizgerd JP. Seedy CD8+ TRM cells in aging lungs drive susceptibility to pneumonia and sequelae. Cellular & Molecular Immunology. 2021 Apr;18(4):787-789. doi: 10.1038/s41423-020-00629-w. Epub 2021 Jan 8.

  17. Traber KE, Dimbo EL, Shenoy AT, Symer EM, Allen E, Mizgerd JP, and Quinton LJ. Neutrophil-Derived Oncostatin M Triggers Diverse Signaling Pathways during Pneumonia. Infect Immun. 2021 Mar 17;89(4):e00655-20. doi: 10.1128/IAI.00655-20. Print 2021 Mar 17.

  18. Barker KA, Etesami NS, Shenoy AT, Arafa EI, Lyon de Ana C, Smith NMS, Martin IMC, Barron AMS, Kepler TB, Browning JL, Kathuria H, Belkina AC, Guillon A, Zhong X, Jones MR, Quinton LJ, and Mizgerd JP. Lung resident memory B cells protect against bacterial pneumonia. J Clin Invest. 2021. Jun 1;131(11):141810. doi: 10.1172/JCI141810.

  19. Odom CV, Kim Y, Burgess CL, Baird LA, Korkmaz FT, Na E, Shenoy AT, Arafa EI, Lam TT, Jones MR, Mizgerd JP, Traber KE, and Quinton LJ. Liver-Dependent Lung Remodeling during Systemic Inflammation Shapes Responses to Secondary Infection. J Immunol. 2021 Sep 1; ji2100254. doi: 10.4049/jimmunol.2100254. 

  20. Shenoy AT, Lyon De Ana C, Arafa EI, Salwig I, Barker KA, Korkmaz FT, Ramanujan A, Etesami NS, Soucy AM, Martin IMC, Tilton BR, Hinds A, Goltry WN, Kathuria H, Braun T, Jones MR, Quinton LJ, Belkina AC, and Mizgerd JP. Antigen presentation by lung epithelial cells directs CD4+ TRM cell function and regulates barrier immunity. Nature Communications 2021 Oct 5;12(1):5834.doi: 10.1038/s41467-021-26045-w.

  21. Shenoy AT*, Lyon De Ana C*, Barker KA, Arafa EI, Martin IMC, Mizgerd JP, and Belkina AC. Comprehensive phenotyping of murine lung resident lymphocytes after recovery from pneumococcal pneumonia. Cytometry A. 2021 Dec 2. doi: 10.1002/cyto.a.24522.

  22. Arafa EI, Shenoy AT, Barker KA, Etesami NS, Martin IM, Lyon De Ana C, Na E, Odom CV, Goltry WN, Korkmaz FT, Wooten AK, Belkina AC, Guillon A, Forsberg EC, Jones MR, Quinton LJ, and Mizgerd JP. Recruitment and training of alveolar macrophages after pneumococcal pneumonia. JCI Insight. 2022 Feb 8:e150239. doi: 10.1172/jci.insight.150239. 

  23. Na E, Allen E, Baird LA, Odom CV, Korkmaz FT, Shenoy AT, Matschulat AM, Jones MR, Kotton DN, Mizgerd JP, Varelas X, Traber KE, and Quinton LJ. Epithelial LIF signaling limits apoptosis and lung injury during bacterial pneumonia.. Am J Physiol Lung Cell Mol Physiol. 2022 Feb 9. doi: 10.1152/ajplung.00325.2021. 


  1. Shenoy AT, and Orihuela CJ. False-colored transmission electron micrograph of Streptococcus pneumoniae serotype 4 strain, TIGR4. Cover image of Clinical and Vaccine Immunology. April 2017, Volume 24, Issue 4



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